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Detailed Description
Title
FSH Responsiveness by a Murine Preosteoclastic Cell line
Department(s)
Biology
Creator(s)
Advisor(s)
Date of Original
6/1/2018
Description
Osteoporosis can be a devastating illness which causes large losses of both monetarily and in terms of quality of life. Interestingly, two of the major risk factors for developing osteoporosis are age and gender as osteoporosis commonly affects postmenopausal women. For decades, osteoporosis was thought be driven by estrogen loss following menopause, however recent research has shown that FSH, the upstream endocrine regulator of estrogen, drives the development of this disease. Using RAW 264.7 cells, we tested the changes that FSH induces in preosteoclastic cells. We noted significant changes in kinase activation and ROS production in an FSH-dependant manner. Similarly, FSH induced gross morphological changes in this cell line.
Genre
thesis
Publisher of Digital Record
Union College Schaffer Library Digital Projects
Source
Union College Schaffer Library Special Collections
Contact Information
Union College Schaffer Library Special Collections, 807 Union St., Schenectady, NY 12308; 518-388-6620; https://www.union.edu/schaffer-library
Harmful Language Statement
Language
English